Gene Therapy

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Gene Therapy

Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents who interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration. Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied in a wide range of diseases, including cancer, peripheral vascular disease, arthritis, neurodegenerative disorders and other acquired diseases.

Even though the range of gene therapy strategies is quite diverse, certain key elements are required for a successful gene therapy strategy (i.e. cloning). The most elementary of these is that the relevant gene must be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited, but until then the starting point for any gene therapy strategy remains gene identification and cloning for relevant genes related to the disease.

Once the gene has been identified and cloned, the next consideration must be expression. Questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research. Currently many debates in the field of gene therapy revolves around the transfer of desired genes to appropriate cells, and then obtaining sufficient levels of expression for disease treatment. Hopefully, future research on gene transfer and tissue-specific gene expression will resolve these issues in the majority of gene therapy protocols. Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and understanding of the target cells to receive the gene therapy.

Gene transfer vector is the mechanism by which the gene is...

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  • Submitted by: cnelson
  • Date Submitted: 05/24/2008 04:30 PM
  • Category: Science
  • Words: 591
  • Pages: 3
  • Views: 120
  • Popularity Rank: 3284

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